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Physics Colloquium Friday, Sept. 19th, 2008, 4:00 P.M.

E300 Math/Science Center; Refreshments at 3:30 P.M. in Room E200

Yi Jiang - Mathematical Modeling and Analysis, Los Alamos National Laboratory

Tumor growth from molecule to tissue: A Cell-based multiscale approach

Cancer remains one of the leading cause of disease death for Americans. Moreover the overall effectiveness of therapeutic treatments is only approximately 50%. Therefore the development of prognostic tools could have immediate impact on the lives of millions of cancer patients. We have developed an integrated, cell-based modeling framework that includes a cellular model for cell dynamics (cell growth, division, death, migration and adhesion), an intracellular regulatory network for cell cycle control and a signaling network for cell decision-making, and a partial differential equation system for extracellular chemical dynamics. This model has produced avascular tumor growth dynamics that agree with tumor spheroid experiments; it has generated realistic vessel sprout morphogenesis in tumor-induced angiogenesis; it has also shown potential for comparing chemotherapeutic strategies for vascular tumor. In particular, we investigate the mechanisms for tumor growth saturation and the roles of VEGF and ECM in tumor angiogenesis. Given the biological realism and flexibility of the model, we believe that it can facilitate a deeper understanding of the cellular and molecular interactions associated with cancer progression and treatment.