Our research is focused on the elucidation of the molecular mechanisms of transcriptional regulation. We use single molecule techniques such as the tethered particle motion technique (TPM), magnetic tweezers (MT), atomic force microscopy (AFM) and single molecule fluorescence together with more traditional biochemical and biomolecular techniques. We develop instrumentation and computational analyses as needed to carry out our investigations. Our research interests span loop-based genetic switches, transcription roadblocks, the interplay between transcription and DNA supercoiling, topoisomerases and DNA mechanics.
Spring 2016 - Laura is editing a Special Issue of Biophysics Reviews entitled “DNA supercoiling, protein interactions and genetic function”. The Issue will appear in early September and will contain contributions by Travers and Muskhelishvili; Levens, Baranello and Kouzine; Corless and Gilbert; Ordu, Lusser and Dekker; Ma and Wang; Dorman; Seol & Neuman; Higgins; Fenfei Leng; Laura Finzi and David Dunlap; Perez and Olson; Harris, Noy and Sutthibutpong.
Read Laura’s editorial and David and Laura’s review!
07/02-08/16 - Yan will participate in the Gordon conference on Single-molecule approaches to Biology in Hong Kong and present a poster entitled “Protein-mediated DNA looping traps surprisingly large topological domains.”
05/10/16 - We welcome rising seniors, Gulnigar Nurikemu and Hayes Burdette-Sapp and rising sophomore Greg Bright to work in the lab for the summer!
03/01/16 - Yan wins 2016 Student Research Achievement Award from biophysical society. Congratulations, Yan!
02/23/16 - Presenting at Biophysical Society Meeting
Please come and see the works from our group at the 2016 Biophysical Society Annual Meeting: Yan (Nanoscale biophysics subgroup, and 1173-Pos/B150), Daniel (917-Plat/Room 511ABC) on Feb. 27~March.2, 2016. We are looking forward to meet you there!