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Dr. Laura Finzi
400 Dowman Dr.
Math and Science Center
Room: N246
Phone: 404-200-1806
Email: lfinzi@emory.edu
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About the lab

Our research is focused on the elucidation of the molecular mechanisms of transcriptional regulation. We use single molecule techniques such as the tethered particle motion technique (TPM), magnetic tweezers (MT), atomic force microscopy (AFM) and single molecule fluorescence together with more traditional biochemical and biomolecular techniques. We develop instrumentation and computational analyses as needed to carry out our investigations. Our research interests span loop-based genetic switches, transcription roadblocks, the interplay between transcription and DNA supercoiling, topoisomerases and DNA mechanics.

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Jul 13, 2021 - Wenxuan's review on "Energetics of twisted DNA topologies" has been published in Boiphysical Journal. Congratulations, Wenxuan!

May 03, 2021 - Laura receives URC grant!

Apr 05, 2021 - Gustavo successfully defended his Honors Thesis!Congratulations Gustavo!

Apr 01, 2021 - Sam successfully defended his Honors Thesis!Congratulations Sam!

Mar 31, 2021 - Stefano successfully defended his Honors Thesis!Congratulations Stefano!

Mar 02, 2021 - Wenxuan and Yan's paper on transcription through lac repressor-mediated loops is posted on BioRxiv: MS ID#: BIORXIV/2021/433568, TITLE: Transcription elongation through lac repressor-mediated DNA loops.

Yan and Wenxuan's paper on the deterministic effect of DNA supercoiling on protein-mediated looping is posted on BioRxiv: MS ID#: BIORXIV/2021/432970, TITLE: Negative DNA supercoiling tunes protein-mediated looping.

Qing and David's paper on the torsional properties of DAP DNA is published in BioRxiv: MS ID#: BIORXIV/2021/432629, TITLE: Nanomechanics of negatively supercoiled diaminopurine-substituted DNA.

Jan 11, 2021 - Jin's review on "Basic mechanisms and kinetics of pause-interspersed transcript elongation" has been published in Nucleic Acids Research. Congratulations, Jin!

Dec 01, 2020 - Joe received Highest Honors from the Thesis committee, Congratulations Joe!

Nov 29, 2020 - Joe Piccolo will be defending his Honors Thesis this Tuesday, December 1, 2020, 4:00 pm EST. His thesis Title: "Electromagnetic Tweezer Development: Improving Single-Molecule Techniques for the Study of DNA Mechanics and Gene Transcription".

We are all cheering for you Joe!

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