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Dr. Laura Finzi
400 Dowman Dr.
Math and Science Center
Room: N246
Phone: 404-200-1806
Email: lfinzi@emory.edu
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About the lab

Our research is focused on the elucidation of the molecular mechanisms of transcriptional regulation. We use single molecule techniques such as the tethered particle motion technique (TPM), magnetic tweezers (MT), atomic force microscopy (AFM) and single molecule fluorescence together with more traditional biochemical and biomolecular techniques. We develop instrumentation and computational analyses as needed to carry out our investigations. Our research interests span loop-based genetic switches, transcription roadblocks, the interplay between transcription and DNA supercoiling, topoisomerases and DNA mechanics.

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News

Jan 16, 2020 - The Finzi-Dunlap lab and the C-Trap facility at Emory University seek a motivated experimentalist to study transcriptional regulation, and supervise the use of the new NSF/Emory-sponsored C-Trap instrument from Lumicks, which integrates optical tweezers, single-molecule fluorescence detection, and microfluidics. The position is a unique opportunity to do cutting edge research and collaborate with a variety of exceptional investigators. More detailed requirements can be found in "News Archives...".

Nov 07, 2019 - Laura was recognized for her excellent teaching by the Gamma Chapter of Georgia, Phi Beta, Kappa Society both in the Spring and Fall of 2018: a rare distinction!

Sep 20, 2019 - Laura received an NSF MRI award to acquire a C-Trap microscope by Lumicks. The microscope will combine a dual optical trap, a 3-color confocal fluorescence detection system and a microfluidic chamber. C-Trap will be part of the facility placed in the Physics department, and available to users. Co-PIs on the award are: Guy Benian (Pathology), Yonggang Ke (BME), Renhao Li (Pediatrics) and Khalid Salaita (Chemistry). For more information about C-Trap check out this link"

Aug 29 - Sep 01, 2019 - Laura and Wenxuan presented our work at the Single Molecular Force Spectropy (SMFS) Workshop in Duke University

Aug 16, 2019 - Our lab was awarded the funding from the NSF for the acquisition of a C-trap microscope (MRI)

April 03, 2019 - Leon Tare and Gustavo Borjas received a "Summer Undergraduate Research at Emory" (SURE) fellowship and an "Initiative for Maximizing Student Development" (IMSD) fellowship, respectively, to continue their research projects during the summer. Congratulation Leon and Gustavo!

March 05, 2019 - Yan Yan gave a platform talk at the annual Biophysical Society meeting in Baltimore, entitled "Supercoiling Makes Protein-mediated Looping of DNA Tethers Deterministic". For more information check out the abstract (DOI: 10.1016/j.bpj.2018.11.1732). Dan Kovari and Wenxuan Xu also gave poster presentations at the meeting. You can find Dan's abstract here (DOI: 10.1016/j.bpj.2018.11.2309), and Wenxuan's here (DOI: 10.1016/j.bpj.2018.11.1164).

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