Professor Laura Finzi receives $1.5M NIH grant renewal for investigation of molecular mechanisms of gene regulation by using single-molecule methods

Professor Laura Finzi has been awarded a $1.5M renewal of her research grant from the National Institutes of Health, entitled “Supercoiling in genome topology and transcription.”  The NIH funding propels the Finzi Laboratory’s mission to understand the molecular mechanisms and physical laws that underlie transcriptional regulation.  State-of-the-art single molecule detection techniques are used to determine protein-DNA structure and functional dynamics.  The work is described in two recent publications in the high-impact (IF, 10.2) journal, Nucleic Acids Research, which feature recent Finzi Lab PhD graduate, Yan Yan, as lead author.

Links to publications:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gky153/4925756

https://academic.oup.com/nar/article/46/5/2370/4818921