Genotype to Phenotype Mapping and the Fitness Landscape of the E. coli lac Promoter

Emory PhD student Jakub Otwinowski (now at the University of Pennsylvania) and Professor Ilya Nemenman analyze the genotype to phenotype map in the bacterium E. coli and discover that the map is highly non-linear, and that the genetic sequence of the natural bacteria is highly optimized for maximum growth in diverse environments. The paper has been ranked as "Recommended" by post-publication reviewers at F1000Prime.

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